A systematic review and meta-analysis concluded that L. reuteri Protectis was the only probiotic to show reduced pain and more pain-free days compared to a placebo in children with functional abdominal pain (FAP).
Despite functional abdominal pain being a common gut problem, there is still no adequate treatment. The aim of this systematic review and meta-analysis was therefore to evaluate the efficacy of strain-specific probiotics on functional abdominal pain in children.
The meta-analysis included nine studies of which six used L. reuteri DSM 17938 and three L. rhamnosus GG (LGG). The primary outcome, number of symptom-free children at the end of the intervention was not achieved, however.
The meta-analysis showed no significant advantages of LGG supplement compared with a placebo in children suffering from functional abdominal pain.
The systematic review and meta-analysis were published online on 17 September 2020 in European Journal of Pediatrics.